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GLP-1 Medications Approved for Adolescents

A comparison of FDA-approved GLP-1 medications for teens: what's available, how they differ, and what the clinical data shows

Written by the Thryvwell Care Team · Medically reviewed by Dr. Glenda Pettaway, MD, MS, FAAP · Updated July 2026 · 5 min read

Not all GLP-1 medications are the same, and not all are approved for adolescents. Currently, two GLP-1 receptor agonists have received FDA approval for chronic weight management in adolescents aged 12 and older, Wegovy® and Saxenda®. Zepbound® is FDA-approved for chronic weight management in adults 18+ but is not FDA-approved for adolescents. Here's what parents should know about each option.

Medication choice for adolescents should be made by a licensed clinician according to current FDA labeling. Compounded semaglutide and tirzepatide are not FDA-approved.

FDA-approved options

Four GLP-1 injection pens side by side: Mounjaro, Ozempic, Wegovy, and Zepbound
GLP-1 injection pens available in the US. Not all are FDA-approved for ages 12–17 — Wegovy® and Saxenda® are the approved adolescent options; Ozempic® and Mounjaro® are approved for type 2 diabetes, not adolescent weight management.

Wegovy® (semaglutide)

Manufacturer: Novo Nordisk
Approval: FDA-approved for adolescents 12+ (2022)
Mechanism: GLP-1 receptor agonist
Dosing: Once-weekly subcutaneous injection
Clinical trial: STEP TEENS: 16.1% BMI reduction vs 0.6% placebo over 68 weeks
Most studied GLP-1 in adolescent populations. Gold standard for pediatric obesity pharmacotherapy.

Saxenda® (liraglutide)

Manufacturer: Novo Nordisk
Approval: FDA-approved for adolescents 12+ (2020)
Mechanism: GLP-1 receptor agonist
Dosing: Once-daily subcutaneous injection
Clinical trial: SCALE Teens: 2.65% BMI reduction vs 1.6% increase with placebo over 56 weeks
First GLP-1 approved for adolescent obesity. Daily dosing may be less convenient than weekly alternatives.

Zepbound® (tirzepatide)

Manufacturer: Eli Lilly
Approval: FDA-approved for chronic weight management in adults 18+; not FDA-approved for adolescents
Mechanism: Dual GIP/GLP-1 receptor agonist
Dosing: Once-weekly subcutaneous injection
Clinical trial: Adolescent clinical trials are ongoing
Zepbound is not FDA-approved for adolescents. Adults 18+ may discuss FDA-approved options with a licensed clinician.

A note on compounded medications

You may have seen advertisements for "compounded semaglutide" or "generic GLP-1" at lower prices. These are not FDA-approved, have not been tested in adolescent clinical trials, and lack the quality controls of brand-name medications.

Thryvwell exclusively prescribes FDA-approved medications with established safety profiles in adolescent populations. When it comes to developing bodies, clinical evidence matters more than cost savings.

Wondering if this applies to your child? The 2-minute eligibility check tells you if Thryvwell could be a fit. No commitment, no payment info.

How your child's physician chooses

The medication selection is individualized based on:

Your child's specific clinical profile and medical history
Insurance coverage and formulary requirements
Dosing convenience (weekly vs. daily)
Individual response and tolerance
Available clinical trial data for their age group

This isn't a one-size-fits-all decision. Your child's physician will discuss the options and recommend the best fit during the clinical intake.

Sources

  • FDA. Wegovy® Prescribing Information (2022)
  • FDA. Saxenda® Prescribing Information: Pediatric Indication (2020)
  • Eli Lilly. Zepbound® prescribing information; adolescent clinical trials are ongoing.
  • Weghuber, D. et al. NEJM (2022); Kelly, A.S. et al. NEJM (2020)

Find out which option is right for your child

Our physicians will recommend the best medication based on your child's individual needs

The information on this page is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting any treatment.

Dr. Glenda Pettaway

Medically reviewed by Dr. Glenda Pettaway, MD, MS, FAAP

Board-certified pediatrician · Thryvwell Chief Medical Officer

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